Beyond TARPs: The Growing List of Auxiliary AMPAR Subunits
نویسندگان
چکیده
A recent paper by von Engelhardt et al. identifies a novel auxiliary subunit of native AMPARs, termed CKAMP44. Unlike other auxiliary subunits, CKAMP44 accelerates desensitization and prolongs recovery from desensitization. CKAMP44 is highly expressed in hippocampal dentate gyrus granule cells and decreases the paired-pulse ratio at perforant path input synapses. Thus, both principal and auxiliary AMPAR subunits control the time course of signaling at glutamatergic synapses.
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عنوان ژورنال:
- Neuron
دوره 66 شماره
صفحات -
تاریخ انتشار 2010